Composition : Dezco Tablet : Each Tablet Contains Deflazacort INN 6mg.
Description : Deflazacort is an oxazoline
derivative of prednisolone with anti-inflammatory and immunosuppressive
Indications : It is indicated for the treatment of a
variety of inflammatory conditions
Dosage and administration : When Deflazacort is used for long
term, the maintenance dose should be kept as low as possible. Dosage may need
to be increased during exacerbation of illness. It should not stop taking
Adults : The usual dose in adults for most
conditions, including rheumatoid arthritis, is in the range of 3-18mg taken
orally per day. In some instances, an initial dose of up to 120mg per day may
be needed. The dose in adults with severe asthma may be up to 48 to 72mg per
day to begin with. This dose may be gradually reduced once the asthma attack
has been controlled.
Other conditions : The dose of Deflazacort depends on
clinical need titrated to the lowest effective dose for maintenance. Starting
doses may be estimated on the basis of ratio of 5mg prednisone or prednisolone
Hepatic Impairment : In patients with hepatic
impairment, blood levels of Deflazacort may be increased. Therefore the dose of
Deflazacort should be carefully monitored and adjusted to the minimum effective
Renal Impairment : In renally impaired patients, no
special precautions other than those usually adopted in patients
Elderly : In elderly patients, no special precautions other than those usually adopted in patients
receiving glucocorticoid therapy are necessary. The common adverse
Children : The usual dose in children with
chronic arthritis is between 0.25-1.0mg/kg bodyweight per day. The usual dose
in children with nephrotic syndrome is 1.5mg/kg bodyweight per day, to begin
with. This dose may be gradually reduced according to the child's response. The
usual dose for children with asthma is between 0.25-1.0mg/kg bodyweight every
other day. Or, as directed by the registered physician.
Use in pregnancy and lactation
: Pregnancy : Deflazacort does
cross the placenta. However, when administered for prolonged periods or
repeatedly during pregnancy, corticosteroids may increase the risk of
Nursing mother : Corticosteroids are excreted in
breast milk, although no data are available for Deflazacort. Doses of up to 50mg
daily of Deflazacort are unlikely to cause systemic effects in the infant.
Infants of mothers taking higher doses than this may have a degree of adrenal
suppression but the benefits of breast feeding are likely to outweigh any
Packing : Dezco Tablet : Each box contains 3 x 10's tablets in blister pack.