Meth tablet

Methotrexate USP


Meth-2.5 : Each film coated tablet contains Methotrexate USP 2.5 mg.

Meth-10 : Each film coated tablet contains Methotrexate USP 10 mg.


Meth (Methotrexate) is used as maintenance therapy for childhood acute lymphoblastic leukaemia. Other uses include choriocarcinoma, and a number of solid tumours.It is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides, and lung cancer, particularly squamous cell and small cell types.It is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkin's lymphomas.It is Indicated in moderate to severe rheumatoid arthritis, malignant disease and psoriasis. It is also indicated in the management of children with active polyarticular-course juvenile idiopathic arthritis, who had as insufficient therapeutic response to, or are intolerant of adequate trial of first line therapy including full dose non-steroidal anti-inflammatory agents (NSAIDs).


In the treatment of rheumatoid arthritis: By mouth, 7.5 mg once weekly as a single dose or divided into 3 doses of 2.5 mg given at intervals of 12 hours, adjusted according to response; maximum total weekly dose 20 mg.

In juvenile idiopathic arthritis : Starting dose is 10 mg/m2/wk increasing upto 20-25 mg/m2/wk in refractory disease. An alternative dosing regimen is 0.3 mg/kg/wk increasing to 0.5 mg/kg/wk after 6 weeks and up to 1 mg/kg/wk if necessary.

Leukaemia in children (maintenance): By mouth, 15 mg/m2 body surface weekly in combination with other drugs.

Maintenance therapy of acute lymphoblastic leukaemia: A common dose of 15 - 30 mg/m2 body surface, once or twice weekly by mouth with other agents.

Choriocarcinoma: Treated with doses of 15 - 30 mg daily by mouth for 5 days at intervals of 1 - 2 weeks for 3 - 5 courses. Doses of 10 - 16 mg/m2 have also been employed in the treatment of breast cancer, often in combination with Cyclophosmamide & Fluorouracil.

In the treatment of psoriasis: Single weekly doses of 10 - 25 mg may be given by mouth, adjusted according to response. Or, as directed by the registered physicians.

Use In Pregnancy And Lactation:

Pregnancy Category X. Meth (Methotrexate) should be avoided during pregnancy. It is teratogenic and fertility may be reduced during therapy but this may be reversible. Following administration to a woman or a man, avoid conception for at least 3 months after stopping. Breast-feeding should be discontinued.


Meth-2.5 : Each box contains 28 tablets in blister pack.

Meth-10 : Each box contains 28 tablets in blister pack.

Prescribing Description

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